Helen M Roche Selected Research

Metabolic Syndrome (Dysmetabolic Syndrome X)

5/2019	Effects of dietary fat on insulin secretion in subjects with the metabolic syndrome.
9/2017	Effect of Dietary Lipids on Endotoxemia Influences Postprandial Inflammatory Response.
1/2017	APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome.
1/2017	Dietary fat quantity and quality modifies advanced glycation end products metabolism in patients with metabolic syndrome.
8/2016	Fatty acids and chronic low grade inflammation associated with obesity and the metabolic syndrome.
12/2015	Insulin resistance determines a differential response to changes in dietary fat modification on metabolic syndrome risk factors: the LIPGENE study.
7/2015	Proteome from patients with metabolic syndrome is regulated by quantity and quality of dietary lipids.
11/2014	Effect of dietary fat modification on subcutaneous white adipose tissue insulin sensitivity in patients with metabolic syndrome.
10/2014	Peripheral blood mononuclear cells as in vivo model for dietary intervention induced systemic oxidative stress.
7/2014	Dietary fat modifies lipid metabolism in the adipose tissue of metabolic syndrome patients.

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Helen M Roche Research Topics

Disease

52	Metabolic Syndrome (Dysmetabolic Syndrome X) 05/2019 - 02/2005
50	Insulin Resistance 01/2022 - 07/2002
37	Inflammation (Inflammations) 11/2021 - 11/2006
34	Obesity 01/2022 - 02/2005
8	Type 2 Diabetes Mellitus (MODY) 01/2018 - 10/2004
6	Atherosclerosis 02/2013 - 06/2004
5	Weight Gain 01/2022 - 06/2009
5	Body Weight (Weight, Body) 01/2021 - 09/2002
4	Neoplasms (Cancer) 07/2015 - 04/2006
4	Abdominal Obesity 03/2012 - 03/2010
4	Cardiovascular Diseases (Cardiovascular Disease) 08/2010 - 09/2002
3	Sarcopenia 01/2022 - 01/2021
3	Hyperlipidemias (Hyperlipidemia) 01/2012 - 12/2006
2	Fatty Liver 01/2022 - 05/2009
2	Overweight 11/2021 - 01/2018
2	Endotoxemia 01/2021 - 09/2017
2	Metabolic Diseases (Metabolic Disease) 01/2017 - 02/2013
2	Hyperglycemia 11/2016 - 03/2010
2	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 01/2016 - 03/2011
2	Glucose Intolerance 02/2015 - 10/2013
2	Hyperemia 01/2014 - 06/2013
2	Dyslipidemias (Dyslipidemia) 07/2012 - 02/2011
2	Weight Loss (Weight Reduction) 07/2012 - 07/2002
2	Hypertriglyceridemia 10/2009 - 02/2006
1	Hypercholesterolemia 01/2022
1	Vascular System Injuries 11/2021
1	Dysbiosis 01/2021
1	Hypertrophy 01/2021
1	Hyperinsulinism (Hyperinsulinemia) 01/2021

Drug/Important Bio-Agent (IBA)

39	Fatty Acids (Saturated Fatty Acids)IBA 10/2020 - 06/2004
29	Dietary Fats (Dietary Fat)IBA 01/2021 - 05/2006
25	Insulin (Novolin)FDA Link 01/2021 - 07/2002
24	Glucose (Dextrose)FDA LinkGeneric 07/2020 - 07/2002
18	LipidsIBA 01/2021 - 10/2004
12	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 09/2017 - 12/2009
11	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2009
11	CytokinesIBA 11/2021 - 03/2010
10	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 01/2022 - 10/2009
10	CholesterolIBA 01/2022 - 09/2002
9	InflammasomesIBA 11/2019 - 08/2012
9	Biomarkers (Surrogate Marker)IBA 01/2018 - 10/2004
9	CarbohydratesIBA 09/2017 - 10/2009
8	Conjugated Linoleic AcidsIBA 01/2020 - 06/2004
8	Triglycerides (Triacylglycerol)IBA 01/2016 - 08/2002
7	Interleukin-6 (Interleukin 6)IBA 01/2021 - 03/2010
6	Monounsaturated Fatty AcidsIBA 01/2017 - 01/2013
6	Lipoproteins (Lipoprotein)IBA 01/2016 - 08/2002
5	NLR ProteinsIBA 01/2021 - 11/2016
4	HDL CholesterolIBA 01/2022 - 02/2006
4	Messenger RNA (mRNA)IBA 01/2021 - 07/2002
4	AdiponectinIBA 01/2018 - 03/2010
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2016 - 10/2007
3	InterleukinsIBA 01/2021 - 10/2007
3	Biological ProductsIBA 01/2019 - 08/2005
3	LeptinIBA 01/2018 - 02/2013
3	Insulin Receptor Substrate ProteinsIBA 01/2017 - 02/2012
3	Apolipoproteins E (ApoE)IBA 01/2017 - 05/2009
3	Apolipoproteins B (ApoB)IBA 01/2016 - 08/2002
3	ProteomeIBA 07/2015 - 02/2012
3	AntioxidantsIBA 01/2015 - 06/2009
3	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 10/2013 - 06/2009
3	Interleukin-10 (Interleukin 10)IBA 10/2012 - 10/2007
3	Linoleic Acid (Linoleate)IBA 05/2009 - 02/2006
2	leucylprolineIBA 01/2022 - 01/2021
2	HDL LipoproteinsIBA 01/2022 - 05/2016
2	Bile Acids and Salts (Bile Acids)IBA 01/2022 - 04/2006
2	NucleotidesIBA 01/2021 - 01/2017
2	FatsIBA 11/2019 - 11/2011
2	EnzymesIBA 01/2019 - 10/2013
2	ApolipoproteinsIBA 01/2016 - 08/2002
2	Superoxide DismutaseIBA 01/2014 - 06/2013
2	Macrophage Migration-Inhibitory FactorsIBA 01/2014 - 11/2012
2	NitritesIBA 01/2014 - 06/2013
2	F2-Isoprostanes (F2 Isoprostanes)IBA 01/2014 - 11/2010
2	Glutathione PeroxidaseIBA 01/2014 - 06/2013
2	C-PeptideIBA 08/2013 - 01/2011
2	Branched-Chain Amino AcidsIBA 07/2013 - 11/2012
2	Amino Acids FDA Link 03/2013 - 11/2012
2	Complement C3 (C3 Complement)IBA 02/2012 - 12/2009
2	trans-11-conjugated linoleic acid cis-9IBA 02/2012 - 03/2007
2	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 06/2011 - 11/2009
2	C-Reactive ProteinIBA 01/2011 - 11/2010
2	NF-kappa B (NF-kB)IBA 05/2010 - 04/2006
2	oxidized low density lipoproteinIBA 04/2010 - 10/2009
1	Leucine (L-Leucine)FDA Link 01/2022
1	Sodium Salicylate (Salicylate, Sodium)IBA 01/2022
1	Pharmaceutical PreparationsIBA 01/2022
1	nasIBA 01/2022
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2021
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2021
1	DNA (Deoxyribonucleic Acid)IBA 01/2021
1	Dietary ProteinsIBA 01/2021
1	Muscle Proteins (Muscle Protein)IBA 01/2021
1	Butyrates (Butyrate)IBA 01/2021
1	SugarsIBA 10/2020
1	alpha-Linolenic Acid (Linolenic Acid)IBA 01/2020

Therapy/Procedure

2	Fat-Restricted Diet (Diet, Fat Restricted) 05/2016 - 10/2013
2	Therapeutics 05/2016 - 04/2016
2	Diet Therapy (Therapy, Diet) 07/2012 - 10/2007
1	Neoadjuvant Therapy 11/2021